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ORIGINAL ARTICLE
Year : 2012  |  Volume : 2  |  Issue : 2  |  Page : 51-55

Association of IL-4 gene polymorphism and age-related macular degeneration in Taiwanese adults


1 Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung; School of Medicine, National Yang-Ming University, Taipei, Taiwan
2 Department of Research and Education, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
3 Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Correspondence Address:
Shwu-Jiuan Sheu
Kaohsiung Veterans General Hospital, Number 386, Ta-Chung First Road, Kaohsiung 813
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.tjo.2012.02.002

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Purpose: The purpose of this study was to determine whether interleukin (IL)-4 genetic variants are associated with age-related macular degeneration (AMD). Methods: The genotyping of IL-4 -590 and intron 3 variable number of tandem repeats (VNTR) was conducted for 171 patients with AMD and 134 controls by using TagMan and polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assays. Results: There was no difference in distribution of age, sex, body mass index, and status of systemic disease between AMD patients and healthy controls. Significantly, more patients were current smokers in the AMD group compared with the controls (p = 0.038). The genotypes of IL-4 -590 and intron 3 VNTR were associated with the risk of AMD in our results. In the stratification analysis, both IL-4 -590 allelic type and smoking status were independently associated with AMD. No interactions between allelic type and smoking were found to contribute to risk of AMD. The mean AMD score was significantly higher in carriers with IL-4 -590 T/T or T/C genotypes compared with those with C/C. Conclusions: Our results support the hypothesis that polymorphisms of IL-4 -590 and intron 3 VNTR might be a genetic marker for the development of AMD.


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