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CASE REPORT
Year : 2015  |  Volume : 5  |  Issue : 4  |  Page : 187-188

Bilateral uveitis associated with concurrent administration of rifabutin and nelfinavir


1 Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
2 Department of Ophthalmology, Kaohsiung Medical University Hospital; School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
3 School of Medicine, Kaohsiung Medical University; Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
4 Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University; Department of Ophthalmology, Yuan's General Hospital, Kaohsiung, Taiwan

Correspondence Address:
Hsien-Chung Lin
Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Number 100, Tzyou 1st Road, Sanmin District, Kaohsiung 807
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.tjo.2014.08.004

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Rifabutin-associated uveitis has been recognized as a dosage-dependent side effect. Previous studies have reported that clarithromycin or fluconazole may elevate concentrations of rifabutin through inhi bition of metabolism through the cytochrome P-450 pathway. Nelfinavir is a protease inhibitor widely used in the treatment of human immunodeficiency virus (HIV) infection. The interactions between protease inhibitors and rifabutin have not been reported in clinical practice. Therefore, we present a case of bilateral uveitis associated with coadministration of rifabutin and nelfinavir. Uveitis did not subside until discontinuation of rifabutin. To our knowledge, this is the first report of uveitis with concurrent administration of rifabutin and nelfinavir. Our finding reminds us that rifabutin dosage should be reduced when it is administered with protease inhibitors.


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