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ORIGINAL ARTICLE
Year : 2017  |  Volume : 7  |  Issue : 4  |  Page : 191-198

Surgical outcome of deep anterior lamellar keratoplasty with air-assisted manual dissection for corneas with previous inflammation or fibrosis


1 Department of Ophthalmology, Limbal Stem Cell Laboratory, Chang Gung Memorial Hospital, Taoyuan, Taiwan
2 Department of Ophthalmology, Lo-Hsu Medical, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Lotung, Taiwan
3 Department of Ophthalmology, Limbal Stem Cell Laboratory, Chang Gung Memorial Hospital, Taoyuan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan
4 Department of Ophthalmology, Limbal Stem Cell Laboratory, Chang Gung Memorial Hospital, Taoyuan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou, Taiwan
5 Department of Ophthalmology, Limbal Stem Cell Laboratory, Chang Gung Memorial Hospital, Taoyuan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou;, Taiwan

Correspondence Address:
David Hui-Kang Ma
Department of Ophthalmology, Limbal Stem Cell Laboratory, Chang Gung Memorial Hospital, No. 5, Fuxing Street, Guishan District, Taoyuan City 33305
Taiwan
Hung-Chi Chen
Department of Ophthalmology, Chang Gung Memorial Hospital, No. 5, Fuxing Street, Guishan District, Taoyuan City 33305
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/tjo.tjo_13_17

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PURPOSE: To report our experience in air-assisted manual dissection deep anterior lamellar keratoplasty (DALK) for the treatment of corneal scar with previous inflammation and fibrosis. MATERIALS AND METHODS: We retrospectively reviewed the medical history of 21 patients (male:female = 13:8 mean age 41.9 years old) with corneal pathology from previous infection and inflammation. Trephination diameter ranged from 7.0 to 8.0 mm, and the graft was oversized by 0.25–0.50 mm. Debulking technique was performed to expose Descemet's membrane after filling stroma with air. Starting from postoperative 3 months, selective suture removal was performed to reduce corneal astigmatism. RESULTS: The mean follow-up period was 59.9 ± 19.8 (20–96) months. Intraoperative microperforation occurred in 2 eyes (9.5%); however, there was no shift to penetrating keratoplasty. Air-bubble tamponade was performed in 7 eyes (33.3%) for postoperative gapping of the graft. There were 2 failed grafts (9.5%) due to corneal ulcer while all the other grafts remained clear throughout follow-up. The mean preoperative best-corrected visual acuity (BCVA) was 1.84 ± 0.66 logMAR, which improved to 0.74 ± 0.63 (P < 0.01). The average sphere power was − 0.88 ± 3.88 diopter (D), average cylinder power 3.03 ± 1.46D, and average endothelial count 1877 ± 375 cells/mm2. CONCLUSION: In severe ocular surface diseases, big-bubble technique frequently failed to separate predescemtic plane; however, it effectively created air-filled stroma which was easier to remove. Although BCVA was suboptimal due to ocular surface disorders, graft survival and clarity rate is high, justifying the application of DALK in these cases.


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