• Users Online: 615
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2020  |  Volume : 10  |  Issue : 1  |  Page : 37-44

Accelerated epithelium-on or accelerated epithelium-off corneal collagen cross-linking: Contralateral comparison study


1 Department of Ophthalmology, School of Medicine, Kastamonu University, Kastamonu, Turkey
2 Department of Ophthalmology, Istanbul Training and Research Hospital, Istanbul, Turkey
3 Department of Ophthalmology, Vezirkopru State Hospital, Samsun, Turkey

Correspondence Address:
Dr. Erdem Yuksel
Department of Ophthalmology, School of Medicine, Kastamonu University, Kuzeykent-Kastamonu
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/tjo.tjo_11_19

Rights and Permissions

PURPOSE: The aim of the study is to compare the accelerated epithelial-on corneal collagen cross-linking (epi-on CXL) and accelerated epithelial-off corneal collagen cross-linking (epi-off CXL) in terms of clinical and confocal microscopy results. MATERIALS AND METHODS: Forty-two eyes of 21 patients with progressive keratoconus and simultaneously undergoing accelerated epi-on CXL in one eye and accelerated epi-off CXL in other eye were evaluated. Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA) with spectacle in logMAR and topographic findings (mean keratometry [Kmean] and maximum keratometry [Kmax]) were recorded at 1, 3, 6, 12, 18, 24, and 30 months. Eyes were compared in terms of subjective pain scores after the procedures. Furthermore, anterior segment optical coherence tomography and confocal microscopy were performed at 1 month. RESULTS: Kmeanand Kmaxwere less than baseline in both the groups; however, the reduction was significantly higher in epi-off CXL than epi-on CXL eyes at 18 and 30 months. The UCVA and BCVA increased approximately 1 Snellen line at the end of mean follow-up in epi-off CXL and in epi-on CXL. Stromal demarcation line for epi-off CXL is 276.4 ± 58.9 while 148.3 ± 24.8 for epi-on CXL (P = 0.001). Furthermore, subepithelial nerves were observed in any eye in epi-off CXL; however, subepithelial nerves were observed in 12 eyes (80%), in epi-on CXL (P = 0.01). CONCLUSION: Both techniques were able to stop progression; however, in contrast to expectations, the pain was felt more in epi-on CXL than epi-off CXL.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed566    
    Printed19    
    Emailed0    
    PDF Downloaded30    
    Comments [Add]    

Recommend this journal