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CASE REPORT
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Blindness due to leptomeningeal carcinomatosis as an initial manifestation of recurrent acute lymphoblastic leukemia


1 Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan
2 Department of Hematology and Oncology, Changhua Christian Hospital, Changhua, Taiwan

Correspondence Address:
Jieh-Ren Jou,
No. 135, Nanxiao Street, Changhua City, Changhua County 500
Taiwan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjo.tjo_107_17

Leptomeningeal carcinomatosis (LC) is an uncommon presentation of acute lymphoblastic leukemia (ALL), and it is a devastating and life-threatening complication. The disease affects all levels of the central nervous system, and most patients present with different multifocal neurological symptoms. This case was a 34-year-old male who had acute bilateral blindness secondary to recurrent ALL with meningeal infiltration. Diagnosis of LC is made based on the clinical symptoms and the test results including cranial and spinal magnetic resonance imaging and cerebrospinal fluid (CSF) survey. The differential diagnosis of meningeal enhancement and early treatment are also important for prognosis. This case had a good visual recovery after treatment.


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    -  Huang YC
    -  Wang CJ
    -  Jou JR
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