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Bilateral corneal melting associated with topical diclofenac 0.1% after cataract surgery in a patient with Sjögren's syndrome


1 Department of Ophthalmology, Cathay General Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
2 Department of Ophthalmology, Cathay General Hospital; Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei; Department of Ophthalmology, College of Medicine, Fu Jen Catholic University, 510, New Taipei City, Taiwan

Correspondence Address:
Yu-Chih Hou,
Department of Ophthalmology, Cathay General Hospital, 280, Ren-Ai Road, Sec. 4, Taipei
Taiwan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjo.tjo_3_19

A 79-year-old female with Sjögren's syndrome (SS) underwent phacoemulsification and lens implantation in both eyes within 2 days. Postoperatively, topical diclofenac 0.1% and tobramycin 0.3% were applied. She presented 10 days later with photophobia, large central corneal melting, and visual acuity of counting finger in both eyes. Diclofenac was discontinued, and systemic doxycycline and steroids were administered. Amniotic membrane transplantation was performed in the left eye with topical steroid and autologous serum 20%. Corneal melting gradually healed in 3 weeks, but the centers of both corneas became thin and opaque. Hyperopic shift and irregular corneal surface were more significant in the right eye than in the left eye. Vision recovered to 0.05 and 0.1 in the right and left eyes, respectively. Topical nonsteroidal anti-inflammatory drugs should be used with caution in cataract surgery in patients with SS.


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