Taiwan Journal of Ophthalmology

REVIEW ARTICLE
Year
: 2018  |  Volume : 8  |  Issue : 4  |  Page : 196--204

Knudson to embryo selection: A story of the genetics of retinoblastoma


Vrushali Athavale, Vikas Khetan 
 Department of Vitreoretina, Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Vikas Khetan
Department of Vitreoretina, Sankara Nethralaya, 18, College Road, Chennai - 600 006, Tamil Nadu
India

Retinoblastoma, the most common primary intraocular malignancy of the young, is a prototype hereditary cancer. Due to its fairly predictable Mendelian inheritance, easily examinable tumors, and early age of presentation, RB has served as the most extensively studied model for genetics in cancer. The genetic strides in RB have progressed at an exponential rate since the 1970s. The highly morbid, reasonably curable and distinctly predictable inheritance pattern of RB; not to mention its propensity to affect our young, forms the basis of aggressively encouraging genetic diagnosis in all patients of RB. In this article, we present the basic and clinically relevant concepts of the genetics retinoblastoma.


How to cite this article:
Athavale V, Khetan V. Knudson to embryo selection: A story of the genetics of retinoblastoma.Taiwan J Ophthalmol 2018;8:196-204


How to cite this URL:
Athavale V, Khetan V. Knudson to embryo selection: A story of the genetics of retinoblastoma. Taiwan J Ophthalmol [serial online] 2018 [cited 2019 Aug 24 ];8:196-204
Available from: http://www.e-tjo.org/article.asp?issn=2211-5056;year=2018;volume=8;issue=4;spage=196;epage=204;aulast=Athavale;type=0