Taiwan Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 9  |  Issue : 3  |  Page : 173--178

Comparison of topical cyclosporine alone and topical loteprednol with cyclosporine in moderate dry eye in Indian population: A prospective study


Shaveta Singla, Lopamudra Sarkar, Mukesh Joshi 
 Department of Ophthalmology, Vardhaman Mahavir Medical College and Safdarjung Hospital, New Delhi, India

Correspondence Address:
Dr. Mukesh Joshi
Room No 430, Eye Opd, 4th Floor, New Opd Building, Safdarjung Hospital, New Delhi - 110 029
India

PURPOSE: The purpose of this study is to compare the efficacy of topical cyclosporine (Cs) 0.05% alone and topical Cs 0.05% with loteprednol 0.5% in patients with moderate dry eye. STUDY DESIGN: This was a comparative, prospective, interventional study. PATIENTS AND METHODS: A total of 140 patients diagnosed with moderate dry eyes were randomly divided into two groups. Group A patients received treatment with topical loteprednol 0.5% started as QID dosage for 2 weeks and tapered to BID dosage over the next 6 weeks, topical Cs 0.05% BID and artificial tears. Group B patients received treatment with topical Cs 0.05% BID and artificial tears. All patients were followed over a period of 6 months with ocular surface disease index (OSDI) questionnaire, tear film break up time (TBUT), corneal fluorescein, and lissamine green staining scores. RESULTS: There was a significant difference in the symptoms and signs of dry eye in the group receiving combination of loteprednol 0.5% and Cs 0.05% as compared to the group receiving Cs alone evident by greater reduction in OSDI score, corneal staining, and improvement in TBUT and Schirmer's test values over a follow-up of 6 months. CONCLUSION: Combination therapy with topical loteprednol and Cs is significantly better than topical Cs alone on alleviating symptoms and signs in moderate dry eye patients.


How to cite this article:
Singla S, Sarkar L, Joshi M. Comparison of topical cyclosporine alone and topical loteprednol with cyclosporine in moderate dry eye in Indian population: A prospective study.Taiwan J Ophthalmol 2019;9:173-178


How to cite this URL:
Singla S, Sarkar L, Joshi M. Comparison of topical cyclosporine alone and topical loteprednol with cyclosporine in moderate dry eye in Indian population: A prospective study. Taiwan J Ophthalmol [serial online] 2019 [cited 2019 Nov 20 ];9:173-178
Available from: http://www.e-tjo.org/article.asp?issn=2211-5056;year=2019;volume=9;issue=3;spage=173;epage=178;aulast=Singla;type=0