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  Indian J Med Microbiol
 

Figure 4: Effect of systemic CCG-203971 administration on postinjury capsular contraction. (a) On day 5 postinjury lens epithelial cells adjacent to the capsular break exhibit nuclear myocardin-related transcription factor-A immunoreactivity (A). Systemic administration of CCG-203971 suppressed the nuclear expression of myocardin-related transcription factor-A in lens epithelial cells beneath the broken capsule (B). Bar, 10 μm. (b) H and E staining histology of an injured lens of control and CCG-203971-treated mice on days 5 and 10. Arrows indicate the edge of the broken capsule. Bar, 100 μm. (c) Contraction of the broken anterior capsule was significantly attenuated by systemic CCG-203971 on day 5, not on day 10, postlens injury. Significant *P <0.05 by Mann-Whitney U test

Figure 4: Effect of systemic CCG-203971 administration on postinjury capsular contraction. (a) On day 5 postinjury lens epithelial cells adjacent to the capsular break exhibit nuclear myocardin-related transcription factor-A immunoreactivity (A). Systemic administration of CCG-203971 suppressed the nuclear expression of myocardin-related transcription factor-A in lens epithelial cells beneath the broken capsule (B). Bar, 10 μm. (b) H and E staining histology of an injured lens of control and CCG-203971-treated mice on days 5 and 10. Arrows indicate the edge of the broken capsule. Bar, 100 μm. (c) Contraction of the broken anterior capsule was significantly attenuated by systemic CCG-203971 on day 5, not on day 10, postlens injury. Significant *<i>P</i> <0.05 by Mann-Whitney U test