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CASE REPORT
Year : 2014  |  Volume : 4  |  Issue : 2  |  Page : 97-99

Post-chemotherapy bilateral limbal stem cell deficiency


1 Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
2 Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung; Chung Hwa University of Medical Technology, Tainan; National Yang-Ming University School of Medicine, Taipei, Taiwan
3 Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung; National Yang-Ming University School of Medicine, Taipei, Taiwan
4 Department of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Correspondence Address:
Jiunn-Liang Chen
Department of Ophthalmology, Kaohsiung Veterans General Hospital, 386, Ta-Chung First Road, Kaohsiung 813, Taiwan
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.tjo.2013.08.003

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We report an extremely rare case of bilateral total limbal stem cell deficiency (LSCD) induced by long-term systemic chemotherapy for squamous cell carcinoma of the lung, and the outcomes of bilateral keratolimbal allograft transplantation (KLAT) in such a case. A 34-year-old male patient had underlying disease of squamous cell carcinoma in the right upper lung with extensive mediastinum and lymph node metastasis and received a series of systemic chemotherapy, including a combination of vinorelbine and cisplatin and a combination of gemcitabine, cisplatin, and docetaxel. According to clinical manifestations of ocular surface disorder, pathology findings, and immunostaining of cytokeratin 13 (CK13), LSCD secondary to systemic chemotherapy was diagnosed. KLAT was performed in both eyes. Although graft rejection developed in the right eye, complete re-epithelialization with favorable visual acuity occurred in the left eye 3 years after limbal transplantation.


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