• Users Online: 811
  • Print this page
  • Email this page

 Table of Contents  
Year : 2015  |  Volume : 5  |  Issue : 3  |  Page : 103-104

Latest advances in the treatment of corneal diseases

Department of Ophthalmology, National University Hospital, Taipei, Taiwan

Date of Web Publication25-Aug-2015

Correspondence Address:
I-Jong Wang
Department of Ophthalmology, National Taiwan University Hospital, No. 7, Zhongshan South Road, Taipei 10002
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.1016/j.tjo.2015.07.003

Rights and Permissions

How to cite this article:
Wang IJ. Latest advances in the treatment of corneal diseases. Taiwan J Ophthalmol 2015;5:103-4

How to cite this URL:
Wang IJ. Latest advances in the treatment of corneal diseases. Taiwan J Ophthalmol [serial online] 2015 [cited 2021 Sep 21];5:103-4. Available from: https://www.e-tjo.org/text.asp?2015/5/3/103/204380

Neurotrophic factors are important factors associated with epithelialization and stromal wound healing after corneal injury.[1] In this issue of the Taiwan Journal of Ophthalmology, Lin et al[2] and Wu et al[3] present two autologous preparations from blood, autose-rum and autologous platelet-rich plasma to treat recalcitrant LASIK-induced neurotrophic epitheliopathy and refractory corneal defects respectively. In Lin et al’s study, all cases of neurotrophic epitheliopathy were healed using conventional autologous serum preparation after LASIK surgery.[2] In Wu et al’s study, three patients with neurotrophic ulcer, exposure corneal ulcer and limbal deficiency with corneal ulcer after HSV keratitis respectively were healed successfully with platelet-rich plasma.[3] Both studies indicate the importance of neurotrophic factors in the treatment of neurotrophic epitheliopathy and stromal defects caused by impairment of trigeminal innervation leading to corneal epithelial breakdown, impairment of healing, and development of corneal ulceration, melting, and perforation.[4] LASIK, diabetes and herpetic infection, as shown in these two studies, will cause impairment of trophic nerve fibers in the trigeminal nerve maintaining the anatomical integrity and function of the ocular surface.[1]

Autologous serum has been shown to contain essential components of tears in comparable concentrations to natural tears.[5] Therefore, it has been used as adjunct or alternative treatment of persistent epithelial defects or neurotrophic ulcer. In fact, autose-rum eye drops was the first hemoderivative product used in the ophthalmology field.[6] However, the presence of leukocytes during the preparation procedure increases the levels of pro-inflammatory cytokines, including IL-6, IL-1 β and TNF-α, which cause further corneal inflammation and ulceration.[7]

Similarly, platelet-rich plasma contains a large pool of proteins and factors such as PDGF, TGF-β, VEGF, IGF-I, hepatocyte growth factor (HGF), angiopoietins, platelet factor-4 (PF-4) and thrombo-spondin, which can also promote corneal epithelialization and stro-mal wound healing like autologous serum.[8] Some preparations such as the new platelet-rich growth factor eye drops are not diluted as usually happens with autologous serum in particular medical devices which are EU and FDA accepted at present.[5] However, it is almost impossible to reach an agreement about a definition of platelet-rich plasma from the variety of preparations described in the literature.[5] There are more than 30 different protocols and platelet-rich plasma products reported in the literature, many of which have been commercialized.[5] Wu et al’s preparation is relatively simple to make and easy to use clinically.[3]

An important point to note is that with both blood derivatives, there is the inevitable increased risk of microbial contamination leading to corneal infection during treatment. The problems of contamination and breakdown of components in these blood-derivative eye drops should be carefully monitored and inspected during preparation and preservation. A standard protocol for preparation needs to be established in the future.

Also in this issue of the Taiwan Journal ofOphthalmology, Wang et al[9] present two cases of occult Descemet’s membrane detachment after phacoemulsification surgery mimicking pseudophakic bullous keratopathy who were scheduled for corneal transplantation. They warned that occult Descemet’s membrane detachment should be suspected in patients with persistent severe corneal edema after phacoemulsification surgery. Corneal transplantation should be deferred for 6–12 months until the surgeon can exclude this possibility. Their case report is interesting and clinically relevant as it has never been reported in the literature. We agree with the opinions from their case presentation. However, the possibility of corneal decompensation during long-term follow-up also needs to be considered.

The final article I highlight from this issue of the journal is that of Sarnicola et al,[10] who present their 4-year follow-up results of suture insertion of graft donor in Descemet stripping automated endothelial keratoplasty. Their unique technique uses a double-armed 10-0 suture with a straight transchamber needle and half-circle needle to insert the folded donor lenticule. Only 9 (4.6%) patients suffered a dislocation of donor tissue; all were successfully reattached with a second air injection. Only 3 (1.5%) eyes developed graft failure. Pupillary block was present in 15 (7.7%) eyes. The results of their method were equivalent to those achieved with current insertion devices such as spoon-shaped glide. Their method provides an alternative should current devices not be available. Their study also demonstrates that both improvement in surgical skills and in the devices used in Descemet stripping automated endothelial keratoplasty are equally important for the outcome of this surgery.

  References Top

Muller LJ, Marfurt CF, Kruse F, Tervo TM. Corneal nerves: structure, contents and function. Exp Eye Res. 2003;76:521–542.  Back to cited text no. 1
Lin SJ, Su CC, Chang DCK, et al. Autologous serum therapy in recalcitrant LASIK-induced neurotrophic epitheliopathy. Taiwan J Ophthalmol. 2015;5:109–113.  Back to cited text no. 2
Wu TE, Chen CJ, Hu CC, Cheng CK. Easy-to-prepare autologous platelet-rich plasma in the treatment of refractory corneal ulcers. Taiwan J Ophthalmol. 2015;5:132–135.  Back to cited text no. 3
Pushker N, Dada T, Vajpayee RB, Gupta V, Aggrawal T, Titiyal JS. Neurotrophic keratopathy. CLAO J. 2001;27:100–107.  Back to cited text no. 4
Anitua E, Muruzabal F, Tayebba A, et al. Autologous serum and plasma rich in growth factors in ophthalmology: preclinical and clinical studies. Acta Ophthalmol. 2015 Apr 2. http://dx.doi.org/10.1111/aos.12710 [Epub ahead of print].  Back to cited text no. 5
Tsubota K, Higuchi A. Serum application for the treatment of ocular surface disorders. Int Ophthalmol Clin. 2000;40:113–122.  Back to cited text no. 6
Pflugfelder SC. Is autologous serum a tonic for the ailing corneal epithelium? Am J Ophthalmol. 2006;142:316–317.  Back to cited text no. 7
Alio JL, Rodriguez AE, WróbelDudzńska D. Eye platelet-rich plasma in the treatment of ocular surface disorders. Curr Opin Ophthalmol. 2015;26:325–332.  Back to cited text no. 8
Wang SW, Tseng SH. Occult Descemet’s membrane detachment after phaco-emulsification surgery mimicking pseudophakic bullous keratopathy. Taiwan J Ophthalmol. 2015;5:136–139.  Back to cited text no. 9
Sarnicola V, Millacci C, Sarnicola E, Sarnicola C, Sabatino F, Ruggiero A. Suture pull-through insertion of graft donor in Descemet stripping automated endo-thelial keratoplasty: Results of 4-year follow-up. Taiwan J Ophthalmol. 2015;5:114–119.  Back to cited text no. 10


Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article

 Article Access Statistics
    PDF Downloaded67    
    Comments [Add]    

Recommend this journal