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REVIEW ARTICLE
Year : 2015  |  Volume : 5  |  Issue : 3  |  Page : 105-108

Rod metabolic demand drives progression in retinopathies


1 College of Physicians & Surgeons, Columbia University, New York, NY, USA
2 Columbia College, Columbia University, New York, NY, USA
3 Bernard & Shirlee Brown Glaucoma Laboratory and Barbara & Donald Jonas Stem Cell Laboratory, Department of Ophthalmology, Columbia University, New York, NY, USA
4 Bernard & Shirlee Brown Glaucoma Laboratory and Barbara & Donald Jonas Stem Cell Laboratory, Department of Ophthalmology, Columbia University; Department of Pathology and Cell Biology and Institute of Human Nutrition, Columbia University, New York, NY, USA

Correspondence Address:
Stephen H Tsang
Department of Ophthalmology, Columbia University, 160 Fort Washington Avenue, Room 513, New York, NY 10032
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.tjo.2015.06.002

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Various factors are thought to cause the development and progression of disease in macular degeneration, diabetic retinopathy, and retinitis pigmentosa. Some of the deleterious processes include oxidative stress, hypoxia, metabolic derangement, genetics, and vasculopathy. In this review, we present a unified theory for the pathophysiology of several retinopathies based on the unique and intense metabolism of rod photoreceptors.


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