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CASE REPORT
Year : 2015  |  Volume : 5  |  Issue : 3  |  Page : 132-135

Easy-to-prepare autologous platelet-rich plasma in the treatment of refractory corneal ulcers


1 Department of Ophthalmology, Shin-Kong Wu Ho-Su Memorial Hospital; School of Medicine, Fu Jen Catholic University; National Yang-Ming University School of Medicine, Taipei, Taiwan
2 Department of Pathology and Laboratory Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
3 Department of Ophthalmology, Shin-Kong Wu Ho-Su Memorial Hospital; School of Medicine, Fu Jen Catholic University, Taipei, Taiwan

Correspondence Address:
Tzu En Wu
Department of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital, Number 95, Wen-Chang Road, Shih-Lin District, Taipei 11120
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.tjo.2014.09.001

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As platelets are rich in growth factors for tissue regeneration, autologous platelet-rich plasma (PRP) has been used to treat some refractory corneal defects. Although PRP is effective, the cost of its preparation is very high. This article presents three cases of refractory corneal ulcer under the prescription of autolo-gous PRP. The autologous PRP used in these cases was easily prepared in the blood bank laboratory. In this paper, we collected three patients with refractory corneal ulcer who were unresponsive to con ventional treatment. The patients presented with neurotrophic ulcer, exposure corneal ulcer, and limbal deciency with corneal ulcer after hepatitic keratitis. Although we easily prepared autologous PRP eye drops using simple laboratory centrifugation, this preparation still had a clinical effect on corneal defect. The mean intervention time was 24 ± 6.9 days. The case with exposure corneal ulcer had significant wound healing and the other two cases felt subjective symptom relief. There were some clinical im provements of refractory corneal ulcers in our three cases. We present the clinical results of three cases and report an easy procedure for the preparation of autologous PRP. Autologous PRP prepared simply in the laboratory, it may be an alternative option for treating refractory corneal ulcer.


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