• Users Online: 843
  • Print this page
  • Email this page


 
 Table of Contents  
CASE REPORT
Year : 2015  |  Volume : 5  |  Issue : 3  |  Page : 136-139

Occult Descemet’s membrane detachment after phacoemulsification surgery mimicking pseudophakic bullous keratopathy


Department of Ophthalmology, National Cheng-Kung University Hospital, College of Medicine, National Cheng-Kung University, Tainan, Taiwan

Date of Web Publication25-Aug-2015

Correspondence Address:
Sung-Huei Tseng
Department of Ophthalmology, National Cheng-Kung University Hospital, College of Medicine, National Cheng-Kung University, 138 Sheng-Li Road, Tainan
Taiwan
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.tjo.2015.04.001

Rights and Permissions
  Abstract 


We herein report two cases of occult Descemet’s membrane detachment (DMD) after phacoemulsifi-cation surgery, which initially presented as persistent corneal edema and had been considered as pseudophakic bullous keratopathy. The patients were thus scheduled to receive corneal transplantation. For Case 1, DMD was incidentally detected by slit-lamp examination 2 months postoperatively, only when part of the cornea became clearer. For Case 2, anterior segment optical coherence tomography demonstrated extensive DMD, which had lasted 5 months after the operation. DMDs in both patients had been successfully attached after descemetopexy. Occult DMD should be suspected in patients with persistent severe corneal edema after phacoemulsification surgery. Corneal transplantation may be avoided by timely diagnosis and treatment of DMD.

Keywords: anterior segment optical coherent tomography, Descemet’s membrane detachment, persistent corneal edema, pseudophakic bullous keratopathy


How to cite this article:
Wang SW, Tseng SH. Occult Descemet’s membrane detachment after phacoemulsification surgery mimicking pseudophakic bullous keratopathy. Taiwan J Ophthalmol 2015;5:136-9

How to cite this URL:
Wang SW, Tseng SH. Occult Descemet’s membrane detachment after phacoemulsification surgery mimicking pseudophakic bullous keratopathy. Taiwan J Ophthalmol [serial online] 2015 [cited 2021 Sep 21];5:136-9. Available from: https://www.e-tjo.org/text.asp?2015/5/3/136/204388




  1. Introduction Top


Descemet’s membrane detachment (DMD) was considered a rare complication following ocular trauma or intraocular surgery.[1] However, as corneal transplantation has evolved into the selective-layered keratoplasty, an increasing number of DMD cases have been reported in patients undergoing deep anterior lamellar keratoplasty and Descemet’s membrane endothelial keratoplasty (DMEK).[2],[3] The most common cause of surgically induced DMD is cataract extraction.[4] DMD can develop at each step of phaco-emulsification, including wound construction, improper visco-elastic cannula placement and injection through the side-port incision, irrigation/aspiration, intraocular lens implantation, or even postoperatively.[5] Clinically, it presents as a translucent membrane in the anterior chamber and extensive DMDs maycreate a “double-anterior-chamber” appearance.[4] As DMD prolongs, the cornea would become edematous due to the absence of corneal endothelial function. Reposition of the detached membrane is the key to induce resolution of corneal edema. Much more common than DMD, but also presenting as corneal edema after cataract surgery, is pseudophakic bullous keratopathy (PBK). This is an irreversible condition caused by extensive loss of corneal endo-thelial cells during cataract surgery. To date, corneal trans plantation is still the mainstay treatment for PBK. With the introduction of endothelial keratoplasty such as Descemet’s membrane stripping automatic endothelial keratoplasty (DSAEK) or DMEK for PBK, most corneal surgeons would advocate the early treatment of PBK before the formation of corneal haze or scar associated with long-term corneal edema.[6]

Because severe and persistent corneal edema may preclude visibility of the delicate structure of Descemet’s membrane (DM), occult DMD patients might be misdiagnosed as PBK, and thus are managed through corneal transplantation without attempts to reposition the DMD. Herein, we report two cases of extensive and occult DMD, mimicking PBK after phacoemulsification surgery, and referred to us for corneal transplantation. Both corneas have cleared up following DMD repositioning with intracameral injection of air or gas, even at 2 months and 5 months after extensive DMD.


  2. Case reports Top


2.1. Case 1

A 67-year-old woman underwent a clinically seemingly un eventful phacoemulsification with a posterior chamber intraocular lens implantation in the left eye in April 2013. Since postoperative Day 1, severe corneal edema in the left eye was noted. Although intensified topical steroid therapy was administered post-operatively, the corneal edema persisted for 2 months without any improvement. Under the impression of PBK, she was referred to us for DSAEK 2 months postoperatively. On initial examination, the patient’s best-corrected visual acuity (BCVA) was only counting fingers in her left eye. Slit-lamp examination of the left eye revealed diffuse corneal edema, which obscured the details of the anterior chamber [Figure 1]A. Because PBK was suspected, she was registered on the waiting list for DSAEK for the treatment of corneal endo-thelial decompensation.
Figure 1: Case 1. Slit-lamp biomicroscopy appearance of the left eye with Descemet’s membrane detachment. (A) At the initial presentation the patient presented with a severe and extensive corneal edema simulating pseudophakic bullous keratopathy 2 months after phacoemulsification. (B) One month later, the inferior one fourth of the cornea became clear. (C) Descemet’s membrane detachment was identified by slit-lamp examination, which extended up to the upper three quarters of the cornea (arrow). (D) One month later, the cornea became clear and, at a high magnification, a 4 mm × 2-mm Descemet’s membrane defect (arrowheads) was noted near the clear corneal incision wound extending to the paracentral cornea.

Click here to view


One month later, at her follow-up visit to our clinic before proceeding to DSAEK, the inferior one fourth of the cornea became clearer [Figure 1]B, which allowed us to more closely observe the details of the anterior chamber. Under slit-lamp examination, we incidentally detected DMD extending up to the upper three quar ters of the cornea where corneal edema persisted [Figure 1]C. To reposition the DMD, we injected approximately 0.1 mL of sterile air into the anterior chamber, which resulted in a successful attach ment of DM on the next day and a clear cornea afterward. When the cornea became clear, a 4 mm × 2-mm DM defect near the clear corneal incision wound was noted [Figure 1]D, attributable to the occurrence of an extensive DMD. During 12 months of follow up, the visual acuity was 20/25 and the cornea remained clear with a central corneal endothelial cell density of 2004 cells/mm2.

2.2. Case 2

A 76-year-old woman was referred to us for DSAEK for the treatment of PBK in November 2013. She had persistently blurred vision in her right eye after a clinically seemingly uneventful phacoemulsification surgery 5 months before in a local clinic. On initial examination, her BCVA was 20/200 in the right eye. Slit-lamp examination of the right eye showed diffuse corneal edema, particularly over the inferior portion of the cornea, which pre vented us from examining the anterior chamber in detail. Based on the lesson learned from Case 1, anterior segment optical coherence tomography (AS-OCT) was performed, which demonstrated extensive DMD involving approximately three fourths of the cornea in the right eye [Figure 2]. Over the region with less corneal edema, the corneal endothelial cell density was measured to be approximately 1329 cells/mm2. Because the clinical course had lasted for almost 5 months, we injected approximately 0.1 mL of 20% sulfur hexaflu-oride (SF6) into the anterior chamber of the eye. One day after the injection, the DM was well attached with rapid resolution of corneal edema. During 6-months follow up, the patient achieved a visual acuity of 20/60. The DM remained attached and notably, a 3 mm × 2-mm DM defect was observed at the entrance of the side port incision, which was attributed to the occurrence of DMD.
Figure 2: Case 2. Anterior segment optical coherence tomography showing a localized Descemet’s membrane detachment.

Click here to view



  3. Discussion Top


To date, PBK remains as one of the leading indications for corneal transplantation.[7] Here, we reported two cases of occult DMD, which was originally diagnosed as PBK because of persistent corneal edema after apparently routine phacoemulsification sur gery, lasting for 2 months and 5 months, respectively. Because the severe corneal edema precluded visibility while investigating the anterior segment in these two patients, it would be difficult to detect DMD simply under slit lamp examination on initial presentation. Fortunately, while Case 1 was on the waiting list for corneal transplantation, the inferior fourth of the affected cornea became clear because of the spontaneous reattachment of the DMD over that area, which led to the detection of the remaining DMD biomicroscopically over the upper three quarters of the cornea. Based on the lesson we learned from Case 1, occult DMD has since been placed at the top of the differential list of diagnosis in patients with persistent corneal edema after phacoemulsification, which enabled us to diagnose the condition without delay in Case 2.

To our knowledge, there has been no report in the literature on DMD patients initially considered as PBK and scheduled to receive corneal transplantation. However, we suspect that such situations might have been overlooked in the past before the widespread availability of AS-OCT or ultrasound biomicroscopy (UBM), and its contribution to persistent postoperative corneal edema may have been underestimated. A recent report from the Singapore National Eye Centre estimated that the incidence rate of acute DMD after phacoemulsification was at least 0.044%/y.[1] Therefore, it is possible that some DMD patients with severe and long-lasting corneal edema may have been treated with corneal transplantation simply because the presence of DMD may be masked by severe corneal edema.

For DMD patients with just mild corneal edema, the detached membrane can be easily observed by slit-lamp biomicroscopy. However, in cases with severe and extensive corneal edema, which was the case in our patients, it would be difficult even for an experienced clinician to detect the DMD without the assistance of AS-OCT or UBM. As shown in Case 2 and those in previous studies,[8],[9] anterior segment image systems are helpful to detect DMD, aid visualization of the detached DM during surgical repo sition of DMD, and monitor the outcomes.

To date, the timing of surgical options for DMD remains debat able. A number of ophthalmologists advocated that once DMD after phacoemulsification surgery has been detected, it should be repo-sitioned as soon as possible.[10],[11],[12] The rationale for immediate intervention relies on the fact that a delayed diagnosis and long-term DMD would allow for wrinkling and DM fibrosis to ensue, which might prevent a successful reattachment afterward, and subsequently resulting in poorer visual outcome.[13] Moreover, if not treated early and properly, delayed DMD may ultimately progress to irreversible corneal decompensation. By contrast, some studies showed that patients with limited and unrolled DMD or DM separated <1 mm from the overlying stroma might develop spon taneous reattachment of DM.[14],[15],[16],[17] Consequently, close observation of such DMD patients might be an acceptable alternative before proceeding to surgical intervention. Although spontaneous reat-tachment of DMD might occur, it usually takes weeks or even several months.[3] Furthermore, it is difficult to predict whether DMD will spontaneously reattach. Thus, surgeons should make a judgment on whether to early repair DMD based on the extent and duration of DMD.

To date, gas bubble tamponade [air, 20% SF6, 14% octa-fluoropropane (C3F8)] is the mainstay treatment for DMD mainly due to its ease of execution and subsequent good outcomes as shown in our patients and those in the literature.[1],[4],[10],[11],[12],[13] Each gas has a different half-life in the anterior chamber, with air having the shortest duration, and C3F8 having the longest duration (lasting for a few weeks). Surgeons can select the air or long-acting gas depending on the extent and duration of DMD. However, either air or long-acting gas should be used with caution due to the fear of pupillary block. For some recalcitrant DMD patients, surgeons may need to consider repeated gas bubble tamponade, manual unscrolling, full-thickness venting stromal incisions, or even suturing.[4]

As the corneal clarity in our patients was restored and reason able endothelial cell density was preserved after 2 months and 5 months of DMD, we are intrigued by the relationship between the duration of DMD and the survival of the corneal endothelial cells over the detached DM. Vinekar et al[18] reported a case of successful reposition of DMD even at 14 months after cataract extraction with good visual prognosis. Therefore, it seems that corneal endothelial cells over the detached DM can survive for a long period in the anterior chamber. Consequently, even if DMD has persisted for years, ophthalmologists should try by all means to reattach the DM before proceeding to corneal transplantation.

In conclusion, ophthalmologists should be aware of occult DMD and have a high index of suspicion of this condition in patients presenting with prolonged corneal edema after phacoemulsifica-tion surgery before making the diagnosis of PBK. Our cases high light the importance of increased awareness of this disease entity and the role of anterior segment imaging system, such as AS-OCTor UBM, in the timely diagnosis of DMD-associated severe corneal edema following phacoemulsification surgery and ultimately avoidance of unnecessary corneal transplantation.

Conflicts of interest: All authors of this submission declare no conflicts of interest relevant to this article.



 
  References Top

1.
Ti SE, Chee SP, Tan DT, Yang YN, Shuang SL. Descemet membrane detachment after phacoemulsification surgery: risk factors and success of air bubble tam-ponade. Cornea. 2013;32:454–459.  Back to cited text no. 1
    
2.
Tu KL, Ibrahim M, Kaye SB. Spontaneous resolution of Descemet membrane detachment after deep anterior lamellar keratoplasty. Cornea. 2006;25: 104–106.  Back to cited text no. 2
    
3.
Dirisamer M, van Dijk K, Dapena I, et al. Prevention and management of graft detachment in Descemet membrane endothelial keratoplasty. Arch Ophthalmol. 2012;130:280–291.  Back to cited text no. 3
    
4.
Chow VW, Agarwal T, Vajpayee RB, Jhanji V. Update on diagnosis and man agement of Descemet’s membrane detachment. Curr Opin Ophthalmol. 2013;24:356–361.  Back to cited text no. 4
    
5.
Morrison LK, Talley TW, Waltman SR. Spontaneous detachment of Descemet’s membrane. Case report and literature review. Cornea. 1989;8:303–305.  Back to cited text no. 5
    
6.
Morishige N, Chikama T, Yamada N, et al. Effect of preoperative duration of stromal edema in bullous keratopathy on early visual acuity after endothelial keratoplasty. J Cataract Refract Surg. 2012;38:303–308.  Back to cited text no. 6
    
7.
Tan JC, Holland SP, Dubord PJ, Moloney G, McCarthy M, Yeung SN. Evolving indications for and trends in keratoplasty in British Columbia, Canada, from 2002 to 2011: a 10-year review. Cornea. 2014;33:252–256.  Back to cited text no. 7
    
8.
Morinelli EN, Najac RD, Speaker MG, Tello C, Liebmann JM, Ritch R. Repair of Descemet’s membrane detachment with the assistance of intraoperative ul trasound biomicroscopy. Am J Ophthalmol. 1996;121:718–720.  Back to cited text no. 8
    
9.
Winn BJ, Lin SC, Hee MR, Chiu CS. Repair of Descemet membrane detachments with the assistance of anterior segment optical coherence tomography. Arch Ophthalmol. 2008;126:730–732.  Back to cited text no. 9
    
10.
Walland MJ, Stevens JD, Steele AD. Repair of Descemet’s membrane detachment after intraocular surgery. J Cataract Refract Surg. 1995;21: 250-253.  Back to cited text no. 10
    
11.
Gault JA, Raber IM. Repair of Descemet’s membrane detachment with intra-cameral injection of 20% sulfur hexafluoride gas. Cornea. 1996;15:483–489.  Back to cited text no. 11
    
12.
Mahmood MA, Teichmann KD, Tomey KF, al-Rashed D. Detachment of Descemet’s membrane. J Cataract Refract Surg. 1998;24:827–833.  Back to cited text no. 12
    
13.
Jain R, Murthy SI, Basu S, Ali MH, Sangwan VS. Anatomic and visual outcomes of descemetopexy in post-cataract surgery Descemet’s membrane detachment. Ophthalmology. 2013;120:1366–1372.  Back to cited text no. 13
    
14.
Minkovitz JB, Schrenk LC, Pepose JS. Spontaneous resolution of an extensive detachment of Descemet’s membrane following phacoemulsification. Arch Ophthalmol. 1994;112:551–552.  Back to cited text no. 14
    
15.
Assia EI, Levkovich-Verbin H, Blumenthal M. Management of Descemet’s membrane detachment. J Cataract Refract Surg. 1995;21:714–717.  Back to cited text no. 15
    
16.
Marcon AS, Rapuano CJ, Jones MR, Laibson PR, Cohen EJ. Descemet’s membrane detachment after cataract surgery: management and outcome. Ophthalmology. 2002;109:2325–2330.  Back to cited text no. 16
    
17.
Mackool RJ, Holtz SJ. Descemet membrane detachment. Arch Ophthalmol. 1977;95:459–463.  Back to cited text no. 17
    
18.
Vinekar A, Sukhija J, Brar GS, Ram J. ‘Late’ functionally successful repair of Descemet’s membrane detachment following phacoemulsification. Eye (Lond). 2007;21:555–556.  Back to cited text no. 18
    


    Figures

  [Figure 1], [Figure 2]


This article has been cited by
1 Latest advances in the treatment of corneal diseases
I-Jong Wang
Taiwan Journal of Ophthalmology. 2015; 5(3): 103
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
1. Introduction
2. Case reports
3. Discussion
References
Article Figures

 Article Access Statistics
    Viewed1222    
    Printed31    
    Emailed0    
    PDF Downloaded79    
    Comments [Add]    
    Cited by others 1    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]