| ORIGINAL ARTICLE |
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| Year : 2017 | Volume
: 7
| Issue : 3 | Page : 138-142 |
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Association of fatty acid-binding protein 2 and fat mass and obesity-associated gene polymorphism with primary open-angle glaucoma
Shania Abbas1, Syed Tasleem Raza1, Anu Chandra1, Luxmi Singh2, Farzana Mahdi1
1 Department of Biochemistry, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India
2 Department Opthalmology, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India
Correspondence Address:
Syed Tasleem Raza
Department of Biochemistry, Era's Lucknow Medical College and Hospital, Lucknow - 226 025, Uttar Pradesh
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/tjo.tjo_10_17
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Purpose: The present study was carried out to investigate the association of fatty acid-binding protein 2 (FABP2) and fat mass and obesity-associated (FTO) gene polymorphism with primary open-angle glaucoma (POAG) cases and controls.
Materials And Methods: This study includes 122 POAG cases and 112 controls. FABP2 and FTO gene polymorphisms in cases and controls were evaluated by polymerase chain reaction-restriction fragment length polymorphism method.
Results: The mean ages were 49.88 ± 12.34 and 53.74 ± 11.87 years in POAG cases and control groups, respectively. The FABP2 gene AA, AT, TT genotype frequencies were 12.90%, 62.40%, 24.80% in POAG cases and 20.60%, 64.70%, 14.70% in healthy controls, respectively. The frequencies of A and T allele in POAG cases were 44.06% and 55.94% as compared to 52.94% and 47.06% in the controls. The FTO gene AA, AT, TT genotype frequencies were 2.00%, 79.20%, 18.80% in cases and 0%, 75.50%, 24.50% in healthy controls, respectively. The frequencies of A and T allele in POAG cases were 41.58% and 58.42% as compared to 37.75% and 62.25% in the controls. No significant difference in the frequencies of FABP2 and FTO genotype was found between POAG cases and controls.
Conclusion: We could not identify the possible association of FABP2 and FTO gene polymorphism with POAG; however, further studies with larger sample size in different population are require to clarify the role of FABP2 and FTO genes in susceptibility to POAG. |
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