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Year : 2020  |  Volume : 10  |  Issue : 3  |  Page : 222-226

Acute zonal occult outer retinopathy presenting as optic neuritis

1 Department of Ophthalmology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
2 Department of Ophthalmology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei; School of Medicine, Fu-Jen Catholic University; School of Medicine, National Taiwan University, New Taipei City, Taiwan
3 Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan

Correspondence Address:
Dr. Pai-Huei Peng
Department of Ophthalmology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjo.tjo_11_20

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Acute zonal occult outer retinopathy (AZOOR) is an outer retinal disorder characterized by the acute loss of visual functions. Herein, we report a case of AZOOR presenting features mimicking optic neuritis. A 17-year-old healthy male reported fogginess in the right eye for 2 weeks. His best-corrected visual acuity was 20/20 in both eyes. Results of a color vision test and pupillary reaction were unremarkable. Funduscopic examination revealed a subtle hyperemic disc surrounded by hyperpigmentation in the right eye. Visual field examination confirmed an enlarged blind spot in the affected eye. Fundus autofluorescence imaging revealed zonal hyperautofluorescence around the optic disc. Fluorescein angiography showed optic disc staining and a window defect in the retinal pigment epithelium. Optical coherence tomography demonstrated loss of the ellipsoid line at the corresponding hyperautofluorescent region. All these characteristics indicated a diagnosis of AZOOR. However, the prolonged P100 wave observed through visual-evoked potential examination, hyperintensity T2 signal at the retrobulbar optic nerve through magnetic resonance imaging, and mild hyperemic optic disc along with optic disc staining through fluorescein angiography resemble the characteristics of optic neuritis. Because the clinical features of AZOOR are similar to those of optic neuritis, ophthalmologists should be able to differentiate between these two diseases to achieve a timely and correct diagnosis.

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