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  Indian J Med Microbiol
 

Figure 1: Mechanism of heavy chain 1–hyaluronic acid/pentraxin 3 formation: (1) In the first step, tumor necrosis factor-stimulated gene 6 protein covalently binds heavy chain 1 of inter-α-trypsin inhibitor and transfers it to high-molecular-weight hyaluronan, at which time heavy chain 1 becomes conjugated and tumor stimulated gene 6 gets released. (2) In the second step, pentraxin 3 is tightly associated with the heavy chain 1–hyaluronic acid complex via binding with heavy chains

Figure 1: Mechanism of heavy chain 1–hyaluronic acid/pentraxin 3 formation: (1) In the  first step, tumor necrosis factor-stimulated gene 6 protein covalently binds heavy chain 1 of inter-α-trypsin inhibitor and transfers it to high-molecular-weight hyaluronan, at which time heavy chain 1 becomes conjugated and tumor stimulated gene 6 gets released. (2) In the second step, pentraxin 3 is tightly associated with the heavy chain 1–hyaluronic acid complex via binding with heavy chains